Markos Leggas : rechercher sur Z-Library

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1

Intensive anti-inflammatory therapy with dexamethasone in patients with non-small cell lung cancer: effect on chemotherapy toxicity and efficacy

Markos Leggas, Kuei-Ling Kuo, Francisco Robert, Gretchen Cloud, Mollie deShazo, Ruiwen Zhang, Mao Li, Hui Wang, Steve Davidson, John Rinehart

Journal:

Cancer Chemotherapy and Pharmacology

Année:

2009

Langue:

english

Fichier:

PDF, 456 KB

english, 2009

2

Reducing signs of aging and increasing lifespan by drug synergy

Huang, Xinhe, Liu, Jun, Withers, Bradley R., Samide, Aaron J., Leggas, Markos, Dickson, Robert C.

Journal:

Année:

2013

Langue:

english

Fichier:

PDF, 619 KB

english, 2013

3

Microbore HPLC method with online microdialysis for measurement of topotecan lactone and carboxylate in murine CSF

Markos Leggas, Yanli Zhuang, Jonathan Welden, Zack Self, Christopher M. Waters, Clinton F. Stewart

Journal:

Journal of Pharmaceutical Sciences

Année:

2004

Langue:

english

Fichier:

PDF, 273 KB

english, 2004

4

Validation of an HPLC method for analysis of DB-67 and its water soluble prodrug in mouse plasma

Jamie Horn, Sherri L. Jordan, Lin Song, Michael J. Roberts, Bradley D. Anderson, Markos Leggas

Journal:

Journal of Chromatography B

Année:

2006

Langue:

english

Fichier:

PDF, 295 KB

english, 2006

5

Factors Affecting theIn VivoLactone Stability and Systemic Clearance of theLipophilicCamptothecin Analogue AR-67

Eyob D. Adane, Zhiwei Liu, Tian-Xiang Xiang, Bradley D. Anderson, Markos Leggas

Journal:

Pharmaceutical Research

Année:

2010

Langue:

english

Fichier:

PDF, 314 KB

english, 2010

6

Nanoparticles Containing Anti-inflammatory Agents as Chemotherapy Adjuvants: Optimization andIn VitroCharacterization

Xiuling Lu, Melissa D. Howard, Marta Mazik, Joshua Eldridge, John J. Rinehart, Michael Jay, Markos Leggas

Journal:

The AAPS Journal

Année:

2008

Langue:

english

Fichier:

PDF, 251 KB

english, 2008

7

Nanoparticles Containing Anti-inflammatory Agents as Chemotherapy Adjuvants II: Role of Plasma Esterases in Drug Release

Xiuling Lu, Melissa D. Howard, Dominique R. Talbert, John J. Rinehart, Philip M. Potter, Michael Jay, Markos Leggas

Journal:

The AAPS Journal

Année:

2009

Langue:

english

Fichier:

PDF, 96 KB

english, 2009

8

High Payload Dual Therapeutic-Imaging Nanocarriers for Triggered Tumor Delivery

Jin-Ki Kim, Hong Yuan, Jingxin Nie, Yu-Tsai Yang, Markos Leggas, Philip M. Potter, John Rinehart, Michael Jay, Xiuling Lu

Journal:

Année:

2012

Langue:

english

Fichier:

PDF, 867 KB

english, 2012

9

Pharmacokinetic Modeling to Assess Factors Affecting the Oral Bioavailability of the Lactone and Carboxylate Forms of the Lipophilic Camptothecin Analogue AR-67 in Rats

Eyob D. Adane, Zhiwei Liu, Tian-Xiang Xiang, Bradley D. Anderson, Markos Leggas

Journal:

Pharmaceutical Research

Année:

2012

Langue:

english

Fichier:

PDF, 1.02 MB

english, 2012

10

Saquayamycins G–K, Cytotoxic Angucyclines from Streptomyces sp. Including Two Analogues Bearing the Aminosugar Rednose

Shaaban, Khaled A., Ahmed, Tamer A., Leggas, Markos, Rohr, Jürgen

Journal:

Journal of Natural Products

Année:

2012

Langue:

english

Fichier:

PDF, 1.37 MB

english, 2012

11

Sunitinib Malate for the Treatment of Metastatic Renal Cell Carcinoma and Gastrointestinal Stromal Tumors

Val R. Adams, Markos Leggas

Journal:

Clinical Therapeutics

Année:

2007

Langue:

english

Fichier:

PDF, 1.40 MB

english, 2007

12

Abrogation of microcystin cytotoxicity by MAP kinase inhibitors and N-acetyl cysteine is confounded by OATPIB1 uptake activity inhibition

Abigail Daily, Noel R. Monks, Markos Leggas, Jeffrey A. Moscow

Journal:

Année:

2010

Langue:

english

Fichier:

PDF, 1.05 MB

english, 2010

13

Expression of the Multi-Drug Resistance Proteins and the Pregnane X Receptor in Treated and Untreated Retinoblastoma

Wilson, Matthew W., Fraga, Charles H., Rodriguez-Galindo, Carlos, Hagedorn, Nikolas, Leggas, Markos L., Stewart, Clinton

Journal:

Current Eye Research

Année:

2009

Langue:

english

Fichier:

PDF, 6.12 MB

english, 2009

14

Validated LC–MS/MS method for simultaneous determination of SIM and its acid form in human plasma and cell lysate: Pharmacokinetic application

Tamer A. Ahmed, Jamie Horn, John Hayslip, Markos Leggas

Journal:

Journal of Pharmaceutical Analysis

Année:

2012

Langue:

english

Fichier:

PDF, 611 KB

english, 2012

15

Pyramidamycins A-D and 3-hydroxyquinoline-2-carboxamide; cytotoxic benzamides from Streptomyces sp. DGC1

Shaaban, Khaled A, Shepherd, Micah D, Ahmed, Tamer A, Nybo, S Eric, Leggas, Markos, Rohr, Jürgen

Journal:

The Journal of Antibiotics

Année:

2012

Langue:

english

Fichier:

PDF, 598 KB

english, 2012

16

Synthesis and evaluation of a series of benzothiophene acrylonitrile analogs as anticancer agents

Penthala, Narsimha Reddy, Sonar, Vijayakumar N., Horn, Jamie, Leggas, Markos, Yadlapalli, Jai Shankar K. B., Crooks, Peter A.

Journal:

Année:

2013

Langue:

english

Fichier:

PDF, 393 KB

english, 2013

17

Biodistribution and bioimaging studies of hybrid paclitaxel nanocrystals: Lessons learned of the EPR effect and image-guided drug delivery

Hollis, Christin P., Weiss, Heidi L., Leggas, Markos, Evers, B. Mark, Gemeinhart, Richard A., Li, Tonglei

Journal:

Journal of Controlled Release

Année:

2013

Langue:

english

Fichier:

PDF, 4.32 MB

english, 2013

18

Stable RNA nanoparticles as potential new generation drugs for cancer therapy

Shu, Yi, Pi, Fengmei, Sharma, Ashwani, Rajabi, Mehdi, Haque, Farzin, Shu, Dan, Leggas, Markos, Evers, B. Mark, Guo, Peixuan

Journal:

Advanced Drug Delivery Reviews

Année:

2014

Langue:

english

Fichier:

PDF, 2.76 MB

english, 2014

19

Pharmacokinetics of high-dose simvastatin in refractory and relapsed chronic lymphocytic leukemia patients

Ahmed, Tamer A., Hayslip, John, Leggas, Markos

Journal:

Cancer Chemotherapy and Pharmacology

Année:

2013

Langue:

english

Fichier:

PDF, 233 KB

english, 2013

20

Protracted dosing of the lipophilic camptothecin analogue AR-67 in non-small cell lung cancer xenografts and humans

Tsakalozou, Eleftheria, Adane, Eyob D., Liang, Yali, Arnold, Susanne M., Leggas, Markos

Journal:

Cancer Chemotherapy and Pharmacology

Année:

2014

Langue:

english

Fichier:

PDF, 762 KB

english, 2014

21

Simvastatin interacts synergistically with tipifarnib to induce apoptosis in leukemia cells through the disruption of RAS membrane localization and ERK pathway inhibition

Ahmed, Tamer A., Hayslip, John, Leggas, Markos

Journal:

Leukemia Research

Année:

2014

Langue:

english

Fichier:

PDF, 2.24 MB

english, 2014

22

Enzymatic Methylation and Structure-Activity-Relationship Studies on Polycarcin V, a Gilvocarcin-Type Antitumor Agent

Chen, Jhong-Min, Shepherd, Micah D., Horn, Jamie, Leggas, Markos, Rohr, Jürgen

Journal:

Année:

2014

Langue:

english

Fichier:

PDF, 697 KB

english, 2014

23

Interactions between Hepatic Mrp4 and Sult2a as Revealed by the Constitutive Androstane Receptor and Mrp4 Knockout Mice

Assem, Mahfoud, Schuetz, Erin G., Leggas, Markos, Sun, Daxi, Yasuda, Kazuto, Reid, Glen, Zelcer, Noam, Adachi, Masashi, Strom, Stephen, Evans, Ronald M., Moore, David D., Borst, Piet, Schuetz, John D.

Journal:

Journal of Biological Chemistry

Année:

2004

Langue:

english

Fichier:

PDF, 855 KB

english, 2004

24

The combination of ezetimibe and ursodiol promotes fecal sterol excretion and reveals a G5G8-independent pathway for cholesterol elimination

Wang, Yuhuan, Liu, Xiaoxi, Pijut, Sonja S., Li, Jianing, Horn, Jamie, Bradford, Emily M., Leggas, Markos, Barrett, Terrence A., Graf, Gregory A.

Journal:

The Journal of Lipid Research

Année:

2015

Langue:

english

Fichier:

PDF, 1.06 MB

english, 2015

25

Cytotoxic Indolocarbazoles from Actinomadura melliaura ATCC 39691

Shaaban, Khaled A., Elshahawi, Sherif I., Wang, Xiachang, Horn, Jamie, Kharel, Madan K., Leggas, Markos, Thorson, Jon S.

Journal:

Journal of Natural Products

Année:

2015

Langue:

english

Fichier:

PDF, 941 KB

english, 2015

26

Development of Idarubicin and Doxorubicin Solid Lipid Nanoparticles to Overcome Pgp-Mediated Multiple Drug Resistance in Leukemia

Ma, Ping, Dong, Xiaowei, Swadley, Courtney L., Gupte, Anshul, Leggas, Markos, Ledebur, Harry C., Mumper, Russell J.

Journal:

Journal of Biomedical Nanotechnology

Année:

2009

Langue:

english

Fichier:

PDF, 1.38 MB

english, 2009

27

Nanotemplate-Engineered Nanoparticles Containing Gadolinium for Magnetic Resonance Imaging of Tumors

Zhu, Donghua, Lu, Xiuling, Hardy, Peter A., Leggas, Markos, Jay, Michael

Journal:

Investigative Radiology

Année:

2008

Langue:

english

Fichier:

PDF, 972 KB

english, 2008

28

Phase 1b trial of proteasome inhibitor carfilzomib with irinotecan in lung cancer and other irinotecan-sensitive malignancies that have progressed on prior therapy (Onyx IST reference number: CAR-IST-553)

Arnold, Susanne M., Chansky, Kari, Leggas, Markos, Thompson, Michael A., Villano, John L., Hamm, John, Sanborn, Rachel E., Weiss, Glen J., Chatta, Gurkamal, Baggstrom, Maria Q.

Journal:

Investigational New Drugs

Année:

2017

Langue:

english

Fichier:

PDF, 356 KB

english, 2017

29

Population pharmacokinetic modelling of rupatadine solution in 6–11 year olds and optimisation of the experimental design in younger children

Santamaría, Eva, Estévez, Javier Alejandro, Riba, Jordi, Izquierdo, Iñaki, Valle, Marta, Leggas, Markos

Journal:

Année:

2017

Langue:

english

Fichier:

PDF, 3.58 MB

english, 2017

30

Pharmacokinetic modeling of gentamicin in treatment of infective endocarditis: Model development and validation of existing models

Gomes, Anna, van der Wijk, Lars, Proost, Johannes H., Sinha, Bhanu, Touw, Daan J., Leggas, Markos

Journal:

Année:

2017

Langue:

english

Fichier:

PDF, 1.66 MB

english, 2017

31

Localization and Functional Characterization of the Rat Oatp4c1 Transporter in an In Vitro Cell System and Rat Tissues

Kuo, Kuei-Ling, Zhu, Haining, McNamara, Patrick J., Leggas, Markos, Butterworth, Michael

Journal:

Année:

2012

Langue:

english

Fichier:

PDF, 1.15 MB

english, 2012

32

Drug Synergy Drives Conserved Pathways to Increase Fission Yeast Lifespan

Huang, Xinhe, Leggas, Markos, Dickson, Robert C., Mata, Juan

Journal:

Année:

2015

Langue:

english

Fichier:

PDF, 2.43 MB

english, 2015

33

Abraxane, the Nanoparticle Formulation of Paclitaxel Can Induce Drug Resistance by Up-Regulation of P-gp

Zhao, Minzhi, Lei, Chunni, Yang, Yadong, Bu, Xiangli, Ma, Huailei, Gong, He, Liu, Juan, Fang, Xiangdong, Hu, Zhiyuan, Fang, Qiaojun, Leggas, Markos

Journal:

Année:

2015

Langue:

english

Fichier:

PDF, 2.38 MB

english, 2015

34

Bayesian Population Physiologically-Based Pharmacokinetic (PBPK) Approach for a Physiologically Realistic Characterization of Interindividual Variability in Clinically Relevant Populations

Krauss, Markus, Tappe, Kai, Schuppert, Andreas, Kuepfer, Lars, Goerlitz, Linus, Leggas, Markos

Journal:

Année:

2015

Langue:

english

Fichier:

PDF, 1.89 MB

english, 2015

35

Topotecan Delivery to the Optic Nerve after Ophthalmic Artery Chemosurgery

Taich, Paula, Requejo, Flavio, Asprea, Marcelo, Sgroi, Mariana, Gobin, Pierre, Abramson, David H., Chantada, Guillermo, Schaiquevich, Paula, Leggas, Markos

Journal:

Année:

2016

Langue:

english

Fichier:

PDF, 318 KB

english, 2016

36

Development of Mithramycin Analogues with Increased Selectivity towards ETS Transcription Factor Expressing Cancers

Mitra, Prithiba, Eckenrode, Joseph M., Mandal, Abhisek, Jha, Amit K., Salem, Shaimaa M., Leggas, Markos, Rohr, Jurgen

Journal:

Journal of Medicinal Chemistry

Année:

2018

Langue:

english

Fichier:

PDF, 642 KB

english, 2018

37

Efavirenz reduces renal excretion of lamivudine in rats by inhibiting organic cation transporters (OCT, Oct) and multidrug and toxin extrusion proteins (MATE, Mate)

Ceckova, Martina, Reznicek, Josef, Deutsch, Birgit, Fromm, Martin F., Staud, Frantisek, Leggas, Markos

Journal:

Année:

2018

Langue:

english

Fichier:

PDF, 2.42 MB

english, 2018

38

Immunohistochemical Detection of Multidrug-Resistant Protein Expression in Retinoblastoma Treated by Primary Enucleation

Wilson, Matthew W., Fraga, Charles H., Fuller, Christine E., Rodriguez-Galindo, Carlos, Mancini, John, Hagedorn, Nikolaus, Leggas, Markos L., Stewart, Clinton F.

Journal:

Investigative Ophthalmology & Visual Science

Année:

2006

Langue:

english

Fichier:

PDF, 1.14 MB

english, 2006

39

Deuterium isotope effects in drug pharmacokinetics II: Substrate-dependence of the reaction mechanism influences outcome for cytochrome P450 cleared drugs

Sun, Hao, Piotrowski, David W., Orr, Suvi T. M., Warmus, Joseph S., Wolford, Angela C., Coffey, Steven B., Futatsugi, Kentaro, Zhang, Yinsheng, Vaz, Alfin D. N., Leggas, Markos

Journal:

Année:

2018

Langue:

english

Fichier:

PDF, 2.21 MB

english, 2018

40

Population pharmacokinetic analysis of AR-67, a lactone stable camptothecin analogue, in cancer patients with solid tumors

Tang, Fei, Tsakalozou, Eleftheria, Arnold, Susanne M., Ng, Chee M., Leggas, Markos

Journal:

Investigational New Drugs

Année:

2019

Langue:

english

Fichier:

PDF, 830 KB

english, 2019

41

Validation of a HPLC/MS Method for Simultaneous Quantification of Clonidine, Morphine and its Metabolites in Human Plasma

Tang, Fei, Bada, Henrietta, Ng, Chee M., Leggas, Markos

Journal:

Biomedical Chromatography

Année:

2019

Langue:

english

Fichier:

PDF, 955 KB

english, 2019

42

Bioanalytical method for quantitative determination of mithramycin analogues in mouse plasma by HPLC‐QTOF

Eckenrode, Joseph M., Mitra, Prithiba, Rohr, Jürgen, Leggas, Markos

Journal:

Biomedical Chromatography

Année:

2019

Langue:

english

Fichier:

PDF, 1004 KB

english, 2019

43

Pharmacokinetic Modeling of the Blood‐Stable Camptothecin Analogue AR‐67 in Two Different Formulations

Liu, Xiaoxi, Adane, Eyob, Tang, Fei, Leggas, Markos

Journal:

Biopharmaceutics & Drug Disposition

Année:

2019

Langue:

english

Fichier:

PDF, 780 KB

english, 2019

44

GZ-11608, a Vesicular Monoamine Transporter-2 Inhibitor, Decreases the Neurochemical and Behavioral Effects of Methamphetamine

Lee, Na-Ra, Zheng, Guangrong, Leggas, Markos, Janganati, Venumadhav, Nickell, Justin R., Crooks, Peter A., Bardo, Michael T., Dwoskin, Linda P.

Journal:

Journal of Pharmacology and Experimental Therapeutics

Année:

2019

Langue:

english

Fichier:

PDF, 2.71 MB

english, 2019

45

Novel Drug Treatments for Ewing Sarcoma

Hayden, Reiya, Leggas, Markos

Journal:

Current Molecular Biology Reports

Année:

2019

Langue:

english

Fichier:

PDF, 1005 KB

english, 2019

46

Phase II Trial of Carfilzomib Plus Irinotecan in Patients With Small-cell Lung Cancer Who Have Progressed on Prior Platinum-based Chemotherapy

Arnold, Susanne M., Chansky, Kari, Baggstrom, Maria Q., Thompson, Michael A., Sanborn, Rachel E., Villano, John L., Waqar, Saiama N., Hamm, John, Leggas, Markos, Willis, Maurice, Rosales, Joseph, Crow

Journal:

Clinical Lung Cancer

Année:

2020

Fichier:

PDF, 962 KB

2020